{"id":5115,"date":"2023-02-14T23:46:46","date_gmt":"2023-02-14T23:46:46","guid":{"rendered":"https:\/\/cds.cdm.depaul.edu\/?page_id=5115"},"modified":"2023-02-15T16:10:46","modified_gmt":"2023-02-15T16:10:46","slug":"depaul-rosalind-franklin-university","status":"publish","type":"page","link":"https:\/\/cds.cdm.depaul.edu\/depaul-rosalind-franklin-university\/","title":{"rendered":"DePaul \u2013 Rosalind Franklin University"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"5115\" class=\"elementor elementor-5115\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e7eb07b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7eb07b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-617e5e8\" data-id=\"617e5e8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2fe4e51 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2fe4e51\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-182f9cd\" data-id=\"182f9cd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-541d3b2 elementor-widget elementor-widget-heading\" data-id=\"541d3b2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DePaul \u2013 Rosalind Franklin University<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4a1c430 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4a1c430\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-16d9a9d\" data-id=\"16d9a9d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f023cc6 elementor-widget elementor-widget-image\" data-id=\"f023cc6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"818\" src=\"https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-1024x818.jpg\" class=\"attachment-large size-large wp-image-5117\" alt=\"\" srcset=\"https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-1024x818.jpg 1024w, https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-300x240.jpg 300w, https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-150x120.jpg 150w, https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-768x614.jpg 768w, https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-1536x1228.jpg 1536w, https:\/\/cds.cdm.depaul.edu\/wp-content\/uploads\/2023\/02\/Rooselin-2048x1637.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-18939ea elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"18939ea\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2b50241\" data-id=\"2b50241\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9414f50 elementor-widget elementor-widget-text-editor\" data-id=\"9414f50\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: center;\"><em>Our group for the DePaul\u00a0 \u2013 Rosalind Franklin University Partnership.<\/em><\/p><h3>Project information\u00a0<\/h3><div>\u00a0<\/div><ul><li><h5><strong>Abstract<\/strong>:\u00a0<\/h5><\/li><\/ul><p style=\"font-weight: 400;\">Neurons in the brainstem reticular formation govern vital motor behaviors such as breathing, vocalization, swallowing, and chewing. Disruption of these circuits in neurodevelopmental and neurodegenerative disorders can lead to central apneas, Sudden Infant Death Syndrome, dysphagia, and speech disorders. Critical for understanding these neural circuits is identification and localization of reticular subpopulations controlling these myriad functions. This proposal has two main AIMS. \u00a0In AIM 1, apply machine learning to cluster reticular formation neurons into groups based on three-dimensional proximity and similarities in their gene expression profiles using data from the open access Allen Institute mouse database (~20,000 distinct genes, 200 \u03bcm voxel resolution) and validated, high resolution, immunohistochemical specimens from transgenic double reporter mice. In AIM 2, use cellular electrophysiology to determine whether neurons within clusters identified by machine learning have similar functional intrinsic properties and whether neurons in adjacent clusters are functionally distinct. The contributions of the proposed research are:<\/p><ol><li style=\"font-weight: 400;\">a novel application of machine learning for structural discovery in the nervous system, akin to an unbiased neuroanatomical \u201cscreen,\u201d that will be rigorously validated with electrophysiology, and<\/li><li style=\"font-weight: 400;\">identification of a number of novel subpopulations underlying functional control of behaviors critical for survival. The overall impact of this proposal will be a highly innovative application of machine learning to neuroscience discovery that may be applied to tissues throughout the body and the elucidation of fundamental principles governing the organization of the brainstem.<\/li><\/ol><ul><li><h5><strong>Professors involved:<\/strong><\/h5><\/li><\/ul><ol><li><p style=\"font-weight: 400;\">Dr. Kaiwen Kam, Associate Professor, Rosalind Franklin University of Medicine and Science<\/p><\/li><li><p style=\"font-weight: 400;\">Dr. Thiru Ramaraj, Assistant Professor, SoC, JCDM, DePaul University<\/p><\/li><li><p style=\"font-weight: 400;\">Dr. Jacon Furst, Professor, SoC, JCDM, DePaul University<\/p><\/li><\/ol><ul><li><h5><strong>Students:<\/strong><\/h5><\/li><\/ul><ol><li><p style=\"font-weight: 400;\">Babita Thadari, Ph.D. Candidate, Rosalind Franklin University of Medicine and Science<\/p><\/li><li><p style=\"font-weight: 400;\">Jordan Skach, Ph.D. Candidate, Rosalind Franklin University of Medicine and Science<\/p><\/li><li><p style=\"font-weight: 400;\">Naga Harivadana Kalapatapu, MS Student, Data Science, SoC, JCDM, DePaul University<\/p><\/li><li><p style=\"font-weight: 400;\">Eddie Cojulun, BS Student, Data Science, SoC, JCDM, DePaul University<\/p><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>DePaul \u2013 Rosalind Franklin University Our group for the DePaul\u00a0 \u2013 Rosalind Franklin University Partnership. Project information\u00a0 \u00a0 Abstract:\u00a0 Neurons in the brainstem reticular formation govern vital motor behaviors such as breathing, vocalization, swallowing, and chewing. Disruption of these circuits in neurodevelopmental and neurodegenerative disorders can lead to central apneas, <a class=\"read-more\" href=\"https:\/\/cds.cdm.depaul.edu\/depaul-rosalind-franklin-university\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5115","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>DePaul \u2013 Rosalind Franklin University - DePaul Center for Data Science<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/cds.cdm.depaul.edu\/depaul-rosalind-franklin-university\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"DePaul \u2013 Rosalind Franklin University - DePaul Center for Data Science\" \/>\r\n<meta property=\"og:description\" content=\"DePaul \u2013 Rosalind Franklin University Our group for the DePaul\u00a0 \u2013 Rosalind Franklin University Partnership. 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